Proteases are one of the largest enzyme family encoded by the human genome. Through catalyzing the hydrolysis of peptide bonds, an enzymatic reaction contributes to the regulation of proteolysis mechanism which is the core of many physiological and pathological processes, such as cell proliferation, tissue remodeling, embryonic development, blood coagulation, blood pressure control, protein activation and maturation, protein catabolism, protein transport, inflammation, infection, and cancer. In particular, the human degradome, which contains a full list of proteases synthesized by human cells, is made up of at least 569 proteases distributed into five broad classes: metalloproteinases, serine, cysteine, threonine, and aspartic proteases.
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Sam 23 Juin 2018 - 4:38