Bone Cancer: Progression and Therapeutic Approaches

D.Heymann, "Bone Cancer: Progression and Therapeutic Approaches"
English | 2009 | ISBN: 012374895X | 504 pages | PDF | 52,1 MB
The epidemiological and clinical importance of bone metastasis has long
been recognized, but the past decade has seen an explosion in the fields
of bone biology and bone cancer research. This period of time has been
marked by a number of key discoveries that have led to the opening up of
entirely new areas for investigation as well as new therapies which
combine surgery and biological therapeutic approaches.

Bone is a common site of cancer metastases - cancer cells commonly
develop in bone and spread to other organ systems through the
bloodstream. For example, the incidence of bone metastases in breast and
prostate cancers is 70%, whereas it is only 30 to 40% in metastatic
lung cancer. In clinical terms, bone metastases have substantial
negative effects on a patient's quality of life and are a main cause of
patient mortality.

Given the global prevalence of breast and prostate cancers, knowledge of
bone biology has become essential for the medical and cancer research
communities. This book provides, all in one resource, the most recent
data on bone cancer development (cellular and molecular mechanisms),
genomic and proteomic analyses, clinical analyses (histopathology,
imaging, pain monitoring), as well as new therapeutic approaches and
clinical trials for primary bone tumors and bone metastases.

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