Epithelial-Mesenchymal Transitions New Advances in Development, Fibrosis and Cancer

E. W. Thompson, D. F. Newgreen, P. Savagner, R.
B. Runyan - Epithelial-Mesenchymal Transitions New Advances in
Development, Fibrosis and Cancer
Published: 2010-12-13 | ISBN: 3805596219 | PDF | 134 pages | 7 MB

This special issue represents a progression through signaling processes,
development, fibrosis and cancer, illustrating common underlying
mechanisms and highlighting the growing recognition of therapeutic
possibilities. Novel molecular pathways are shown in the context of
known regulators, and many articles offer specific insights into
therapeutic targeting. Not surprisingly, several articles relate to the
signaling pathways activated by the common anchor transforming growth
factor (TGF)-beta in relation to epithelial-mesenchymal transition
(EMT). A number of new mechanisms with therapeutic implications are
described, specifically the interplay between the non-Smad PI3
kinase-Akt-mTOR axis and EMT-associated invasion in response to
TGF-beta, the unexpected role of c-Abl in repressing TGF-beta1-induced
EMT, the cooperativity between oncostatin M, hepatocyte growth factor
and TGF-beta1 in lung carcinoma EMT, and the roles of dystroglycan and
periostin in developmental EMT associated with gastrulation and palate
fusion, respectively. Collectively, the issue presents the full spectrum
of interest in EMT today.

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